Fioricet—a blend of butalbital, acetaminophen, and caffeine—is a go-to treatment for tension headaches, but patients often have questions. This guide clears up five common concerns: how Fioricet works, whether it’s safe to mix with coffee, possible side effects, medication interactions, and proper storage. It also emphasizes the pharmacist’s vital role in ensuring safe and effective use. If you’re taking Fioricet or considering it, your pharmacist is your best source for clear, reliable guidance.